Effect of X-rays on the somatic chromosomes of the exotic fish, Tilapia mossambica

Male and female T. mossambica were x-rayed with 100 r and the meta-phase chromosome aberrations in their gill epithelia were studied at 13 different intervals against suitable control. The chromosomes of males appeared more radiosensitive than those of females. Among the diploid complement of 44 chromosomes, the individual type aberrations were non-random in both sexes. The longest pair of chromosomes, taken as the marker pair, was found very highly radio-sensitive, while the remaining 21 pairs as non-markers were somewhat resistant to x-radiation when the observed and the expected numbers were subjected to statistical analysis. The break in the marker chromosome was also non-randomly distributed as the distal half had a significantly large number of breaks

On quantum advantage in the random access code protocols with two-qubit states

Random access code (RAC) is an important communication task to conditionally access remote $n$-bit string even if one has limited information about it. Here we consider the version of this task assisted with shared randomness (quantum/classical) with fixed local dimension of two and the communicated information of a single classical bit. Quantum advantage is obtained in terms of worst-case success probability, $p$. We demonstrate that, there exist quantum strategies utilizing bipartite qubit state with invertible correlation matrix that outperform the corresponding dimensionally equivalent shared classical randomness source for RAC protocols when $n=2,3$. In case of $n\geq 4$ such quantum strategies do not exist for the RAC protocols considered here.Comment: 6 pages, 1 figure, improved presentatio

Modeling cancer metabolism on a genome scale

Cancer cells have fundamentally altered cellular metabolism that is associated with their tumorigenicity and malignancy. In addition to the widely studied Warburg effect, several new key metabolic alterations in cancer have been established over the last decade, leading to the recognition that altered tumor metabolism is one of the hallmarks of cancer. Deciphering the full scope and functional implications of the dysregulated metabolism in cancer requires both the advancement of a variety of omics measurements and the advancement of computational approaches for the analysis and contextualization of the accumulated data. Encouragingly, while the metabolic network is highly interconnected and complex, it is at the same time probably the best characterized cellular network. Following, this review discusses the challenges that genome‐scale modeling of cancer metabolism has been facing. We survey several recent studies demonstrating the first strides that have been done, testifying to the value of this approach in portraying a network‐level view of the cancer metabolism and in identifying novel drug targets and biomarkers. Finally, we outline a few new steps that may further advance this field

Mutation accumulation and fitness effects in hybridogenetic populations: a comparison to sexual and asexual systems

Background: Female only unisexual vertebrates that reproduce by hybridogenesis show an unusual genetic composition. They are of hybrid origin but show no recombination between the genomes of their parental species. Instead, the paternal genome is discarded from the germline prior to meiosis, and gametes (eggs only) contain solely unrecombined maternal genomes. Hence hybridogens only transmit maternally inherited mutations. Hybridity is restored each generation by backcrossing with males of the sexual parental species whose genome was eliminated. In contrast, recombining sexual species propagate an intermixed pool of mutations derived from the maternal and paternal parts of the genome. If mutation rates are lower in female gametes than males, it raises the possibility for lower mutation accumulation in a hybridogenetic population, and consequently, higher population fitness than its sexual counterpart. Results: We show through Monte-Carlo simulations that at higher male to female mutation ratios, and sufficiently large population sizes, hybridogenetic populations can carry a lower mutation load than sexual species. This effect is more pronounced with synergistic forms of epistasis. Mutations accumulate faster on the sexual part of the genome, and with the purifying effects of epistasis, it makes it more difficult for mutations to be transmitted on the clonal part of the genome. In smaller populations, the same mechanism reduces the speed of Muller\'s Ratchet and the number of fixed mutations compared to similar asexual species. Conclusion: Since mutation accumulation can be less pronounced in hybridogenetic populations, the question arises why hybridogenetic organisms are so scarce compared to sexual species. In considering this, it is likely that comparison of population fitnesses is not sufficient. Despite competition with the sexual parental species, hybrid populations are dependent on the maintenance of – and contact with – their sexual counterpart. Other problems may involve too little genetic diversity to respond to changing environments and problems in becoming hybridogenetic (e.g. disruption of meiosis and subsequent infertility or sterility). Yet, lower mutation accumulation in hybridogenetic populations opens the possibility that hybridogenetic species can develop into new sexual species once recombination is re-established and reproductive isolation from sexual ancestors has occurred

Hubble Space Telescope Observations of Sub-Damped Lyman-alpha Absorbers at z < 0.5, and Implications for Galaxy Chemical Evolution

We report observations of four sub-damped Lyman-alpha (sub-DLA) quasar absorbers at z<0.5 obtained with the Hubble Space Telescope Cosmic Origins Spectrograph. We measure the available neutrals or ions of C, N, O, Si, P, S, Ar, Mn, Fe, and/or Ni. Our data have doubled the sub-DLA metallicity samples at z<0.5 and improved constraints on sub-DLA chemical evolution. All four of our sub-DLAs are consistent with near-solar or super-solar metallicities and relatively modest ionization corrections; observations of more lines and detailed modeling will help to verify this. Combining our data with measurements from the literature, we confirm previous suggestions that the N(HI)-weighted mean metallicity of sub-DLAs exceeds that of DLAs at all redshifts studied, even after making ionization corrections for sub-DLAs. The absorber toward PHL 1598 shows significant dust depletion. The absorbers toward PHL 1226 and PKS 0439-433 show the S/P ratio consistent with solar, i.e., they lack a profound odd-even effect. The absorber toward Q0439-433 shows super-solar Mn/Fe. For several sub-DLAs at z<0.5, [N/S] is below the level expected for secondary N production, suggesting a delay in the release of the secondary N or a tertiary N production mechanism. We constrain the electron density using Si II* and C II* absorption. We also report different metallicity vs. Delta V_90 relations for sub-DLAs and DLAs. For two sub-DLAs with detections of emission lines from the underlying galaxies, our measurements of the absorption-line metallicities are consistent with the emission-line metallicities, suggesting that metallicity gradients are not significant in these galaxies.Comment: 77 pages, 13 figures; accepted for publication in the Astrophysical Journal. Submitted (in the original form) May 26, 2014; accepted Apr. 15, 201